Additional Possibility of Data Analysis of Enzyme Inhibition and Activation 2. Geometrical Portraits of Enzymatic Reactions for Data Processing in Enzyme Inhibition
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چکیده
منابع مشابه
Mechanism-Based Studies of the Active Site-Directed Inhibition and Activation of Enzyme Transketolase
Derivatives of phenyl-keto butenoic acids have been reported to be inhibitors of pyruvate decarboxylase, (PDC). The inhibition of transketolase, a thiamine requiring enzyme such as PDF, by meta nitrophenyl derivative of 2-oxo-3-butenoic acid (MNPB) is reported here. These studies indicate that the inhibitor binds to the enzyme at the active site. A two-step inhibition was observed, first th...
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15 صفحه اولAnalysis of kinetic data for irreversible enzyme inhibition.
Many organophosphorus compounds are irreversible inhibitors of acetylcholinesterase. The methods used in the literature to determine the inhibition kinetic constants usually involve either manual determination of the slope at various points along the inhibition progress curve or fitting polynomials to the curve. The present study investigates the use of non-linear-regression analysis to determi...
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ژورنال
عنوان ژورنال: Journal of Biological Sciences
سال: 2004
ISSN: 1727-3048
DOI: 10.3923/jbs.2005.92.97